6. The table below lists pharmacokinetic parameters for doripenem in a healthy 70 kg
individual:
Volume of distribution 16.4 L Total plasma clearance 15.7 L/h
Plasma protein binding 8.0% Renal clearance 10.7 L/h
Terminal half-life approx. 1 h
The recommended dosing regimen for treatment of complicated urinary tract infection is 500 mg by IV
infusion over 1 hour, every 8 hours, for 10 days.
Using the data supplied, describe the disposition of doripenem over the course of the
recommended regimen. (12 marks)