Tumor immunology lecture 1, 2, 3 & 4 22 April 2024 16:06 Tumour immunoloav - lecture 1 Key points cancer basics and evidence for immune responses to tumours Tumour-specific antigens and tumour-associated antigens Avoiding immune destruction is a hallmark of cancer cells Deregulating celular energetics Resisting CoHl death Genome instability & mutation Sustaining proliferative signaling Inducing angiogenesis Evading growth suppressors Avoiding' immune destruction 4 8 Enabling replicative . immortality A Tumor- promoting inflammation Activating invasion & metastasio Cancer arises from stepwise accumulation of mutations Advanced Immunology Page 1
adenomatous polyps: large hyper- proliferation smaa adenocarcinoma severe dysplasia (pre cancerous polyp) cancer L Benign http://www.hopkinscoloncancercenter.org/CMS Malignant DNA hypomethylation activation of K-ras ! loss of 18q TSG 1 loss of p53 loss of APC normal epithelium hyperplastic epithelium early-+intermediate + late adenomas carcinoma invasion & metastasis Tumours are composed of many cell types Advanced Immunoloav Page 2
· Granulocyte · Cotinophil - NK.cel · Platelet Hematopoetic origin · Mast cell . 8 cell . Macrophage . CTL Tumor microenvironment Vascular endothelium Mesenchymal origin · Pericybe · Fibroblant Cancer Research Reviews Advanced Immunoloav Page 3