00:01
So we're looking at some very strange chromosomes.
00:06
We've got a chromosome that has had a vast number of rearrangements.
00:12
And this is typically in a single chromosome.
00:17
The break points are tightly clustered, so that's one important point.
00:21
And another important point is that the copy number of the segments is one or zero.
00:26
So they've either been deleted or they haven't been deleted.
00:30
But importantly, they haven't multiplied.
00:33
So breakpoints clustered and no replication of segments.
00:42
Or i'll switch out for duplication.
00:44
No duplication.
00:46
Duplication of segments.
00:49
Now we're looking at two possible ways this could happen.
00:51
The images for the merriman textbook.
00:53
We have the progressive rearrangement where we have a one by one building up for rearrangements.
01:00
Or we have a catastrophe.
01:01
Model where our chromosome breaks in multiple places and is then stick together randomly.
01:10
Which of these is most likely? well, a, the very important point here is if you have a rearrangements model, you have a duplication of segments...