How are the different gene segments arranged in the lambda light chain locus?
Added by Stefanie H.
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The lambda light chain locus is located on chromosome 22 in humans. Show more…
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Which of the following Ig gene segment arrangements would most closely match that of lambda light chain DNA? a. 30 V segments followed by 3 sets of J-C segments b. 30 V segments followed by 3 J segments and then 3 C segments c. 40 V segments followed by 5 J segments and then 1 C segment d. 40 V segments followed by 5 sets of J-C segments, only 4 of which are functional e. 40 V segments followed by 25 D segments, then 6 J segments followed by at least 5 C segments QUESTION 41 Which of the following DNA regions in an RSS would contain an A-T rich sequence? a. the nonamer b. a 12-base pair spacer c. a 23-base pair spacer d. the heptamer e. both the nonamer and heptamer regions
Rabeya Z.
The immunoglobulin light chain does not have a D segment. In humans, there are two different possible light chain proteins, termed kappa and lambda. Assume that there are 35 V segments and 5 J segments in the human kappa light chain region, and there are 30 V segments and 4 J segments in the human lambda light chain region. How many possible light chain genes can be created from these different segments, simply due to combinatorial diversity? Please enter an exact number.
Adi S.
Below is the germline DNA for the kappa light-chain gene in humans. The intervening sequence between regions is denoted by "---". ---|≡≡V1≡≡|---|≡≡V2≡≡|---|≡≡V3≡≡|---|≡≡V4≡≡|---|≡≡V5≡≡|---|≡≡Vn≡≡|--//--|≡J1≡|--|≡J2≡|--|≡J3≡|--|≡J4≡|--|≡J5≡|---|≡≡C≡≡|--- Below is the final functional kappa light-chain protein produced from this DNA in a mature B-cell. |≡≡V3≡≡||≡J2≡||≡≡C≡≡| Which of the following is the correct DNA arrangement after somatic recombination occurs in a mature B-cell? ○---|≡≡V3≡≡||≡J2≡||≡≡C≡≡|--- ○---|≡≡V1≡≡|---|≡≡V2≡≡|---|≡≡V3≡≡|---|≡≡V4≡≡|---|≡≡V5≡≡|---|≡≡Vn≡≡|--//--|≡J1≡|--|≡J2≡|--|≡J3≡|--|≡J4≡|--|≡J5≡|---|≡≡C≡≡|--- ○---|≡≡V1≡≡|---|≡≡V2≡≡|---|≡≡V3≡≡||≡J2≡|--|≡J3≡|--|≡J4≡|--|≡J5≡|---|≡≡C≡≡|--- ○---|≡≡V3≡≡||≡J2≡|--|≡J3≡|--|≡J4≡|--|≡J5≡|---|≡≡C≡≡|--- ○---|≡≡V1≡≡|---|≡≡V2≡≡|---|≡≡V3≡≡|---|≡J2≡|--|≡J3≡|--|≡J4≡|--|≡J5≡|---|≡≡C≡≡|--- Which of the following is the correct pre-mRNA arrangement in a mature B-cell? ○---|≡≡V1≡≡|---|≡≡V2≡≡|---|≡≡V3≡≡||≡J2≡|--|≡J3≡|--|≡J4≡|--|≡J5≡|---|≡≡C≡≡|--- ○---|≡≡V3≡≡||≡J2≡||≡≡C≡≡|---
Suman K.
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