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Several spherical nanocarriers that include peptide chains can form self-assembly by H-bonding between each peptide, and they will release the drug when the pH decreases because the H-bonding between each peptide is destroyed. 1.1 I would like to know why H-bonding is destroyed when the pH decreases. 1.2 How does pH affect the strength of H-bonding? 2. In the case where the charge balance in the nanospheres formed by the co-assembly of the original positive nanocarrier and negative drug molecules is maintained at neutral pH, this balance is destroyed under acidic conditions. Therefore, the drug is released from the nanocarrier. 2.1 I would like to know why the charge balance is destroyed when the pH decreases or increases. 2.2 How does pH affect the charge between the positive nanocarrier and negative drug molecules? 2.3 How does charge affect the strength of H-bonding? Title_with_topic: Understanding the Effects of pH on H-Bonding and Charge Balance in Nanocarriers

          Several spherical nanocarriers that include peptide chains can form self-assembly by H-bonding between each peptide, and they will release the drug when the pH decreases because the H-bonding between each peptide is destroyed. 
1.1 I would like to know why H-bonding is destroyed when the pH decreases.
1.2 How does pH affect the strength of H-bonding?

2. In the case where the charge balance in the nanospheres formed by the co-assembly of the original positive nanocarrier and negative drug molecules is maintained at neutral pH, this balance is destroyed under acidic conditions. Therefore, the drug is released from the nanocarrier.
2.1 I would like to know why the charge balance is destroyed when the pH decreases or increases.
2.2 How does pH affect the charge between the positive nanocarrier and negative drug molecules?
2.3 How does charge affect the strength of H-bonding?

Title_with_topic: 
Understanding the Effects of pH on H-Bonding and Charge Balance in Nanocarriers

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